The COM Port number that the NDS I software is trying to use is invalid. If you are using an USB adaptor or USB to serial converter, a COM Port number was assigned to your adaptor by the driver at the time of first installation. This COM Port number will need to be entered in the NDS I software under Settings->Communication.
If you don't know what Port number was assigned to your adaptor you can find in Device Manager under "Ports (COM & LPT)".
Please note: NDS I will only work with Com Port numbers 1-16. So if your adaptor has a Com Port number above 16 change it to something lower first. You can do it through Device Manager by going to Properties->Port Settings->Advanced.